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Dexpramipexole

Catalog No. TQ0175 CAS 104632-28-2

Synonyms: 右旋普拉克索, KNS-760704, R-(+)-Pramipexole, (R)-Pramipexole

Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.

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Dexpramipexole, CAS 104632-28-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.
In vitro	Dexpramipexole has neuroprotective effects. Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

Synonyms	右旋普拉克索, KNS-760704, R-(+)-Pramipexole, (R)-Pramipexole
Molecular Weight	211.33
Formula	C10H17N3S
CAS No.	104632-28-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL (47.32 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11. 2. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6. 3. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.

Related Products

Related compounds with same targets

Dexpramipexole Sumanirole maleate 13-Hydroxyisobakuchiol Bacopaside X UCM-1306 Eticlopride hydrochloride Beta-CIT-FP cis-(Z)-Flupentixol dihydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dexpramipexole 104632-28-2 G蛋白偶联受体神经科学 Dopamine Receptor KNS-760704 (R)-Pramipexole R-(+)-Pramipexole Inhibitor inhibitor inhibit

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