Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
2 mg | In stock | $ 138.00 | |
5 mg | In stock | $ 226.00 | |
10 mg | In stock | $ 345.00 | |
25 mg | In stock | $ 586.00 | |
50 mg | In stock | $ 838.00 | |
100 mg | In stock | $ 1,160.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 289.00 |
Description | Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
Targets&IC50 | Factor D:(kd)0.54 nM |
In vitro | Danicopan (ACH-4471) inhibits the proteolytic activity of purified factor D and its natural substrate factor B binding to C3b, blocking the production of Bb fragments in a dose-dependent manner, with an IC50 value of 0.015 μM. Danicopan (ACH-4471) effectively inhibits hemolysis with IC50 values from 0.0040 μM to 0.027 μM (IC90 values from 0.015 μM to 0.11 μM). |
Synonyms | ACH-4471 |
Molecular Weight | 580.41 |
Formula | C26H23BrFN7O3 |
CAS No. | 1903768-17-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (447.96 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Danicopan 1903768-17-1 Immunology/Inflammation Complement System ACH 4471 inhibit ACH4471 ACH-4471 Inhibitor inhibitor