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Danicopan

Catalog No. T8509   CAS 1903768-17-1
Synonyms: ACH-4471

Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

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Danicopan Chemical Structure
Danicopan, CAS 1903768-17-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
2 mg In stock $ 138.00
5 mg In stock $ 226.00
10 mg In stock $ 345.00
25 mg In stock $ 586.00
50 mg In stock $ 838.00
100 mg In stock $ 1,160.00
1 mL * 10 mM (in DMSO) In stock $ 289.00
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Purity: 99.88%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Targets&IC50 Factor D:(kd)0.54 nM
In vitro Danicopan (ACH-4471) inhibits the proteolytic activity of purified factor D and its natural substrate factor B binding to C3b, blocking the production of Bb fragments in a dose-dependent manner, with an IC50 value of 0.015 μM. Danicopan (ACH-4471) effectively inhibits hemolysis with IC50 values from 0.0040 μM to 0.027 μM (IC90 values from 0.015 μM to 0.11 μM).
Synonyms ACH-4471
Molecular Weight 580.41
Formula C26H23BrFN7O3
CAS No. 1903768-17-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 260 mg/mL (447.96 mM), sonification is recommended.

TargetMolReferences and Literature

1. Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475.

Related compound libraries

This product is contained In the following compound libraries:
Orally Active Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Pediatric Drug Library Immunology/Inflammation Compound Library NO PAINS Compound Library Drug Repurposing Compound Library Clinical Compound Library Covalent Inhibitor Library

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Keywords

Danicopan 1903768-17-1 Immunology/Inflammation Complement System ACH 4471 inhibit ACH4471 ACH-4471 Inhibitor inhibitor

 

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