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Clemastine fumarate

Catalog No. T0147 CAS 14976-57-9

Synonyms: HS-592 (fumarate), Meclastine fumarate, Meclastine (fumarate)

Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.

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Clemastine fumarate, CAS 14976-57-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 51.00
200 mg	In stock	$ 76.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.8%

Biological Description

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Storage & Solubility Information

Description	Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
Targets&IC50	H1 receptor:3 nM
In vitro	In rats, Clemastine Fumarate (5-20 mg/kg) significantly inhibits yeast polysaccharide-induced paw edema and croton oil-induced ear swelling in a dose-dependent manner.
In vivo	In HL-60 cells, Clemastine Fumarate (IC50=3 nM) effectively inhibits histamine-induced increases in Ca2+ levels. In the human leukemia cell line K562 and the human B-lymphoblast cell line SB, concentrations of Clemastine Fumarate ≥25 μM significantly suppress both natural killer (NK) cell and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. Additionally, Clemastine Fumarate potently inhibits the HERG K+ channel in HEK 293 cells stably expressing the channel (IC50=12 nM).

Synonyms	HS-592 (fumarate), Meclastine fumarate, Meclastine (fumarate)
Molecular Weight	459.97
Formula	C25H30ClNO5
CAS No.	14976-57-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (50 mM)

References and Literature

1. Seifert R, et al. Mol Pharmacol, 1992, 42(2), 227-234. 2. Nair MP, et al. Cell Immunol, 1983, 81(1), 45-60. 3. Merlos M, et al. J Pharmacol Exp Ther, 1997, 280(1), 114-121. 4. Ridley JM, et al. J Mol Cell Cardiol, 2006, 40(1), 107-118. 5. Nörenberg W, et al. J Biol Chem, 2011, 286(13), 11067-11081. 6. Xie D, Niu L, Gao C, et al. Clemastine Improves Hypomyelination in Rats with Hypoxic–Ischemic Brain Injury by Reducing Astroglia-Derived IL-1β via Autophagy[J]. 2020.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Approved Drug Library Immunology/Inflammation Compound Library

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Keywords

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