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Cichoric Acid

Catalog No. TL0006 CAS 6537-80-0

Synonyms: Dicaffeoyltartaric acid, Chicoric Acid

Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.

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Cichoric Acid, CAS 6537-80-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 117.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 297.00

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Purity: 98.57%

Purity: 97.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.
Targets&IC50	HIV-I integrase:0.8 μM
Source	Natural Products > Asteraceae > Cichorium

Synonyms	Dicaffeoyltartaric acid, Chicoric Acid
Molecular Weight	474.37
Formula	C22H18O12
CAS No.	6537-80-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 347 mg/mL (731.50 mM)

References and Literature

1. King P J, Robinson W E. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase[J]. Journal of virology, 1998, 72(10): 8420-8424. 2. Raduner S, et al. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.[J]. Journal of Biological Chemistry, 2006, 281(20):14192-14206.

Citations

1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Natural Product Library for HTS Anti-Viral Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Prostate Cancer Compound Library Natural Product Library Anti-Cancer Compound Library Oxidation-Reduction Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cichoric Acid 6537-80-0 Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb Proteases/Proteasome HIV Protease Reactive Oxygen Species p-Akt inhibit ROS anti-inflammatory Apoptosis glucose uptake Dicaffeoyltartaric acid insulin resistance glucosamine PI3K/Akt antioxidant mitochondria Chicoric Acid Inhibitor MAPK antidiabetic inhibitor

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