Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 70.00 | |
2 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 172.00 | |
10 mg | In stock | $ 272.00 | |
25 mg | In stock | $ 483.00 | |
50 mg | In stock | $ 691.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 213.00 |
Description | CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers. |
In vitro | In PBMCs, GDC-0917 (0.1 -10000 nM) induces the reduction of cIAP1 levels in a concentration-dependent manner. GDC-0917(0.1 µM) shows more than 80% inhibition[1]. |
In vivo | In the MDA-MB-231-X1.1 Breast Cancer Xenograft, GDC-0917 (0.08-16.3 mg/kg) dose-dependently exhibits antitumor activity with a <11% decrease of body weight. The clearance values are 12.0, 27.0, 15.3 and 67.6 mL/min/kg for mouse, rat, dog and monkey[1]. |
Synonyms | GDC-0917 |
Molecular Weight | 564.7 |
Formula | C29H36N6O4S |
CAS No. | 1446182-94-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (79.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CUDC-427 1446182-94-0 Apoptosis IAP GDC0917 GDC 0917 CUDC427 GDC-0917 CUDC 427 inhibitor inhibit