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CGS 15943

Catalog No. T14944 CAS 104615-18-1

CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.

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CGS 15943, CAS 104615-18-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 223.00
50 mg	In stock	$ 333.00
100 mg	In stock	$ 498.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 99.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM , respectively.
Targets&IC50	A1 receptor:3.5 nM (ki), A2A receptor:4.2 nM (ki), p110γ:1.1 μM, A2B receptor:16 nM (ki), p110δ:8.47 μM, A3 receptor:51 nM (ki)
In vitro	CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ (IC50: 1.1 μM). CGS 15943 shows slight inhibition on p110δ (IC50: 8.47 μM). CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[3].

Molecular Weight	285.69
Formula	C13H8ClN5O
CAS No.	104615-18-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.22 mg/mL (42.77 mM), Sonification is recommended.

References and Literature

1. Gao Y, et al. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5. 2. Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91. 3. Edling CE, et al. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Inhibitor Library Orally Active Compound Library HIF-1 Signaling Pathway Compound Library Glycolysis Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Breast Cancer Compound Library

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(2S,3R,4S)-4-Hydroxyisoleucine AS-605240 SRX3177 1,3-Dicaffeoylquinic acid Seletalisib PI3Kα/mTOR-IN-1 TASP0415914 Niazimicin

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Keywords

CGS 15943 104615-18-1 GPCR/G Protein Neuroscience PI3K/Akt/mTOR signaling PI3K Adenosine Receptor Phosphoinositide 3-kinase P1 receptor CGS15943 inhibit CGS-15943 Inhibitor inhibitor

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