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CBS9106

Catalog No. T14885 CAS 1076235-04-5

Synonyms: SL-801

CBS9106 (SL-801) is a reversible oral inhibitor of CRM1 with CRM1 degrading and antitumor activities. CBS9106 arrests the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells.

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CBS9106, CAS 1076235-04-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 293.00
5 mg	In stock	$ 722.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00

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Purity: 99.09%

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Description	CBS9106 (SL-801) is a reversible oral inhibitor of CRM1 with CRM1 degrading and antitumor activities. CBS9106 arrests the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells.
In vitro	CBS9106 (1-400 nM; 24 hours) decreases CRM1 protein expression levels in a dose-dependent manner. CBS9106 (0.01-10 μM; 72 hours) sensitizes cells to radiation and to suppress the growth of a variety of cancer cell lines. The estimated IC50 values are range from 22.3 or 35.6 nM in multiple myeloma (MM).1S or RPMI-8226 cells and from 3 to 278 nM in 60 other human cancer cell lines [1].
In vivo	In mice bearing human MM xenograft models, CBS9106 (31.25-62.5 mg/kg for 5 times weekly, 125 mg/kg for 3 times weekly; p.o.; 2 weeks) significantly suppresses tumor growth at dose levels of 62.5 or 125 mg/kg.

Synonyms	SL-801
Molecular Weight	419.83
Formula	C18H21ClF3N3O3
CAS No.	1076235-04-5

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sakakibara K, et al. CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. Blood. 2011 Oct 6;118(14):3922-31.

Related Products

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CRM1-IN-1 KPT330,(E)- KPT185 CRM1-IN-2 Verdinexor Leptomycin A Selinexor (KPT-330) KPT276

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CBS9106 1076235-04-5 Membrane transporter/Ion channel CRM1 CBS-9106 SL801 SL 801 CBS 9106 SL-801 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.