Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 164.00 | |
25 mg | In stock | $ 278.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 96.00 |
Description | Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling. |
In vitro |
Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2].
|
Source |
Molecular Weight | 248.32 |
Formula | C15H20O3 |
CAS No. | 30557-81-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (100.68 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Bisabolangelone 30557-81-4 MAPK p38 MAPK Inhibitor inhibit inhibitor