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Betahistine

Catalog No. T4195 CAS 5638-76-6

Synonyms: PT 9 base, Vasomotal, Serc base

Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.

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Betahistine, CAS 5638-76-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 42.00
200 mg	In stock	$ 51.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.87%

Purity: 97.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PT 9 base, Vasomotal, Serc base
Molecular Weight	136.19
Formula	C8H12N2
CAS No.	5638-76-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (220.27 mM)

References and Literature

1. Albu S,et al . Treatment of Meniere's disease with intratympanic dexamethazone plus high dosage of betahistine. Am J Otolaryngol. 2016 May-Jun;37(3):225-30. 2. Yi C, et al. Efficacy and acceptability of oxcarbazepine vs. carbamazepine with betahistine mesilate tablets in treating vestibular paroxysmia: a retrospective review. Postgrad Med. 2016 Apr 18:1-4. 3. Barak N, et al. A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Betahistine to Counteract Olanzapine-Associated Weight Gain. J Clin Psychopharmacol. 2016 Jun;36(3):253-6. doi: 10.1097/JCP.202002020020200200200489. PubMed PMID: 27028981. 4. Chen YY, et al. Puerarin and betahistine treatment of vertebrobasilar ischemia vertigo: A meta-analysis of randomized controlled trials. Exp Ther Med. 2016 Mar;11(3):1051-1058. 5. Lian J, et al. Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications. Pharmacol Res. 2016 Apr;106:51-63.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Approved Drug Library GPCR Compound Library EMA Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library High Solubility Pharmacophore Fragment Library ReFRAME Related Library Drug-Fragment Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Betahistine 5638-76-6 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor disease arthritis Inhibitor episode antipsychotic PT 9 base inhibit Vasomotal CIA Rheumatoid Ménière Serc base schizophrenia inhibitor

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