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Baicalein

Catalog No. T2858   CAS 491-67-8
Synonyms: 5,6,7-Trihydroxyflavone

Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.

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Baicalein Chemical Structure
Baicalein, CAS 491-67-8
Pack Size Availability Price/USD Quantity
50 mg In stock $ 33.00
100 mg In stock $ 48.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 97.25%
Purity: 95.79%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor.
Targets&IC50 xanthine oxidase:3.12 mM.
In vitro Baicalein suppresses mitogen-induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb-induced proliferation and cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB while inhibiting thioredoxin activity in the nuclear compartment[2]. Baicalein suppresses the proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes[3].
In vivo Baicalein suppresses induction of graft versus host disease while not inhibiting the homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo[2]. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats[4].
Cell Research MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3].
Source
Synonyms 5,6,7-Trihydroxyflavone
Molecular Weight 270.24
Formula C15H10O5
CAS No. 491-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13.5 mg/mL (50 mM)

TargetMolReferences and Literature

1. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5. 2. Xing-Cong M , Wanjun Y , Zhijun D , et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway[J]. Drug Design, Development and Therapy, 2016:1419-. 3. Kong EK, et al. A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensiverats. Eur J Pharmacol. 2011 May 11;658(2-3):175-81. 4. Meng X, Mao Z, Li X, et al. Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice[J]. Oncotarget. 2017, 8(25): 40305.

TargetMolCitations

1. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855. 2. Yan H, Zhang R, Yan G, et al.Validation of baicalein and oridonin as nonspecific SARS‐CoV‐2 main protease inhibitors.Phytotherapy Research.2023 3. Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767. 4. Xiao T, Cui M, Zheng C, et al. Both Baicalein and Gallocatechin Gallate Efficaciously Inhibit SARS-CoV-2 Replication by Targeting Mpro and Sepsis in Mice. Inflammation. 2021: 1-13. 5. Xue H, Huo Y, Hu Y, et al. The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells. Theriogenology. 2022 6. Lu H, Li X, Wang G, et al. Baicalein Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo. International Journal of Molecular Sciences. 2021, 22(11): 5829. 7. Meng X, Mao Z, Li X, et al. Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice. Oncotarget. 2017, 8(25): 40305.

Related compound libraries

This product is contained In the following compound libraries:
Tibetan medicine Compound Library Metabolism Compound Library Chinese Pharmacopoeia Natural Product Library Mitochondria-Targeted Compound Library Ferroptosis Compound Library FDA-Approved Kinase Inhibitor Library Food as Medicine Compound Library Cell Cycle Compound Library Anti-Aging Compound Library Traditional Mongolian Medicine Compound Library

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Keywords

Baicalein 491-67-8 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology Ferroptosis Influenza Virus ROS Xanthine Oxidase Inhibitor 5,6,7-Trihydroxyflavone inhibit inhibitor

 

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