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Catalog No. T2858   CAS 491-67-8
Synonyms: 5,6,7-Trihydroxyflavone

Baicalein is a xanthine oxidase inhibitor.

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Baicalein, CAS 491-67-8
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Baicalein is a xanthine oxidase inhibitor.
Targets&IC50 xanthine oxidase:3.12 mM.
In vitro Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment[2]. Baicalein suppresses proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes[3].
In vivo Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo[2]. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats[4].
Cell Research MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3].
Synonyms 5,6,7-Trihydroxyflavone
Molecular Weight 270.24
Formula C15H10O5
CAS No. 491-67-8


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 13.5 mg/mL (50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5. 2. Xing-Cong M , Wanjun Y , Zhijun D , et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway[J]. Drug Design, Development and Therapy, 2016:1419-. 3. Kong EK, et al. A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensiverats. Eur J Pharmacol. 2011 May 11;658(2-3):175-81. 4. Meng X, Mao Z, Li X, et al. Baicalein decreases uric acid and prevents hyperuricemic nephropathy in mice[J]. Oncotarget. 2017, 8(25): 40305.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Flavonoid Natural Product Library HIF-1 Signaling Pathway Compound Library Traditional Chinese Medicine Monomer Library Anti-Obesity Compound Library Inhibitor Library Polyphenolic Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Oxidation-Reduction Compound Library

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