Powder: -20°C for 3 years | In solvent: -80°C for 2 years
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 223.00 | |
50 mg | In stock | $ 433.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 122.00 |
Description | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. |
In vitro | BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1] |
Molecular Weight | 711.63 |
Formula | C33H33N3O15 |
CAS No. | 1137359-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 93 mg/mL (130.7 mM)
H2O: <1 mg/mL
Ethanol: 93 mg/mL (130.7 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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BRD7552 1137359-47-7 Others promoter BRD-7552 islets human inhibit epigenetic ductal changes insulin BRD 7552 primary Inhibitor cells inhibitor