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BRD7552

Catalog No. T6793 CAS 1137359-47-7

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

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BRD7552, CAS 1137359-47-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 223.00
50 mg	In stock	$ 433.00
1 mL * 10 mM (in DMSO)	In stock	$ 122.00

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Purity: 98%

Biological Description

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Description

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

In vitro

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

Molecular Weight	711.63
Formula	C33H33N3O15
CAS No.	1137359-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 93 mg/mL (130.7 mM)

H2O: <1 mg/mL

Ethanol: 93 mg/mL (130.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yuan Y, et al. Chem Biol. 2013, 20(12), 1513-1522.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Transcription Factor-Targeted Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BRD7552 1137359-47-7 Others promoter BRD-7552 islets human inhibit epigenetic ductal changes insulin BRD 7552 primary Inhibitor cells inhibitor

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