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Astragaloside A

Catalog No. T6395   CAS 83207-58-3
Synonyms: Astragalin A, Astramembrannin I

Astragaloside A (Astramembrannin I) (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases.

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Astragaloside A Chemical Structure
Astragaloside A, CAS 83207-58-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 46.00
5 mg In stock $ 58.00
10 mg In stock $ 85.00
25 mg In stock $ 162.00
50 mg In stock $ 243.00
100 mg In stock $ 369.00
200 mg In stock $ 558.00
500 mg In stock $ 898.00
1 mL * 10 mM (in DMSO) In stock $ 85.00
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Purity: 99.87%
Purity: 99.76%
Purity: 99.35%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Astragaloside A (Astramembrannin I) (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases.
In vitro Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester. [1]
In vivo Astragaloside IV significantly reduces infarct size in dogs subjected to coronary ligation in vivo. [1] Astragaloside IV attenuates isoproterenol-induced subendocardial necrosis, serum lactate dehydrogenase and creatine kinase activation, and lipid oxide product malondialdehyde formation in rats. It also reduces sarcoplasmic reticulum Ca(2+)-uptake ability and Ca(2+)-ATPase (SERCA2a) activity as well as SERCA2a mRNA expression in myocardial injury rats. [2]
Kinase Assay In vitro PI3Kγ Kinase Assay: Human PI3Kγ (100 ng) is incubated at RT with kinase buffer (10 mM MgCl2, 1 mM β-glycerophosphate, 1 mM DTT, 0.1 mM Na3VO4, 0.1% Na Cholate and 15 M ATP/100 nCi γ[33]ATP, final concentrations) and lipid vesicles containing 18 M PtdIns and 250 M of PtdSer (final concentrations), in the presence of AS-252424 or DMSO. Kinase reaction is stopped by adding 250 g of Neomycin-coated Scintillation Proximity Assay (SPA) beads and preceded.
Source
Synonyms Astragalin A, Astramembrannin I
Molecular Weight 784.97
Formula C41H68O14
CAS No. 83207-58-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 93 mg/mL (118.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Zhang WD, et al. Planta Med, 2006, 72(1), 4-8. 2. Xu, X.L, et al. Eur J Pharmacol, 2007, 568(1-3), 203-212.

Related compound libraries

This product is contained In the following compound libraries:
Anti-COVID-19 Traditional Chinese Medicine Compound Library Calcium Channel Compound Library Selected Plant-Sourced Compound Library Ferroptosis Compound Library Chinese Pharmacopoeia Natural Product Library Traditional Mongolian Medicine Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Anti-Tumor Natural Product Library Tibetan medicine Compound Library

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Keywords

Astragaloside A 83207-58-3 Membrane transporter/Ion channel Metabolism Calcium Channel Astragalin A Astramembrannin I inhibitor inhibit

 

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