Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 38.00 | |
10 mg | In stock | $ 63.00 | |
25 mg | In stock | $ 109.00 | |
50 mg | In stock | $ 178.00 | |
100 mg | In stock | $ 263.00 | |
500 mg | In stock | $ 647.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 41.00 |
Description | Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH). |
In vitro | Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. [1] Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine. [2] |
In vivo | Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. [1] Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). [3] Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. [4] Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. [5] |
Synonyms | SL 77499-10, Alfuzosin HCl |
Molecular Weight | 425.91 |
Formula | C19H27N5O4·HCl |
CAS No. | 81403-68-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.7 mg/mL (25 mM)
H2O: 10.7 mg/mL (25 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Alfuzosin hydrochloride 81403-68-1 GPCR/G Protein Neuroscience Adrenergic Receptor bladder neck inhibit Alfuzosin urination SL 77499-10 prostatic Beta Receptor Alfuzosin Hydrochloride Alfuzosin HCl Inhibitor BPH inhibitor