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Aleplasinin

Catalog No. T29856 CAS 481629-87-2

Synonyms: PAZ 417, PAZ-417, PAZ417

Aleplasinin is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies.

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Aleplasinin, CAS 481629-87-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PAZ 417, PAZ-417, PAZ417
Molecular Weight	425.52
Formula	C28H27NO3
CAS No.	481629-87-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 245 mg/mL (575.77 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jacobsen JS, et al. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8754-9. 2. Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4. 3. Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.

Related Products

Related compounds with same targets

GW-6604 TM5007 Toddalolactone TM5275 sodium TM5441 Loureirin B UK-371804 Aleplasinin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aleplasinin 481629-87-2 代谢 PAI-1 Plasminogen activator inhibitor-1 Serpin family Abeta Inhibitor Alzheimer's disease BBB-penetrated PAZ 417 β-amyloid peptide PAZ417 orally active PAZ-417 memory deficiency Amyloid-β inhibit inhibitor

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