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Acriflavine

Catalog No. T18911 CAS 8048-52-0

Synonyms: Acriflavinium chloride 3,6-Acridinediamine mix

Acriflavine (Acriflavinium chloride 3,6-Acridinediamine mix) is a papain-like protease (PL(pro)) inhibitor, a fluorescent dye for labeling high molecular weight RNAs, has antimicrobial and anticancer activity, inhibits SARS-CoV-2 and other β-coronaviruses, and can be used for research on leukemia. be used to study leukemia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Acriflavine, CAS 8048-52-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 34.00
100 mg	In stock	$ 47.00
500 mg	In stock	$ 105.00
1 g	In stock	$ 152.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acriflavine (Acriflavinium chloride 3,6-Acridinediamine mix) is a papain-like protease (PL(pro)) inhibitor, a fluorescent dye for labeling high molecular weight RNAs, has antimicrobial and anticancer activity, inhibits SARS-CoV-2 and other β-coronaviruses, and can be used for research on leukemia. be used to study leukemia.
In vitro	A novel candidate drug, Acriflavine, exhibits significant dose-dependent inhibition of A549 cell viability at low concentrations (1, 2, 5, and 10 μM)[1].
In vivo	Nude mice bearing xenografts of A549 cells were intraperitoneally injected with 2 mg/kg ACF daily for six weeks. The results indicate that treatment with ACF leads to a reduction in tumor size[1].
Animal Research	CML mice are treated daily with acriflavine (8 mg/kg) or PBS via intraperitoneal injection, for 10 days starting from day 7 after bone marrow transplantation [2].

Synonyms	Acriflavinium chloride 3,6-Acridinediamine mix
Molecular Weight	468.98
Formula	C27H25ClN6
CAS No.	8048-52-0

Storage

keep away from direct sunlight,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20 mg/mL (77.00 mM)

References and Literature

1. Lee CJ,et al. Antitumor activity of acriflavine in lung adenocarcinoma cell line A549. Anticancer Res. 2014 Nov;34(11):6467-72. 2. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292. 3. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Acriflavine 8048-52-0 Microbiology/Virology SARS-CoV Antibacterial Acriflavinium chloride 3,6-Acridinediamine mix inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.