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AM 374

Catalog No. T68492 CAS 86855-26-7

Synonyms: HDSF, Hexadecanesulfonyl fluoride

AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AM 374, CAS 86855-26-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 138.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 328.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease research.
Targets&IC50	Amidase:13 nM
In vitro	AM 374 (0-9 nM) inhibits the degradation of anandamide in N18TG2 cells.[1]
In vivo	AM 374 (20 μg ; intraventricular injection, once) has no effect on lever pressing in FR5, but when used in combination with anandamide (intraperitoneal injection), it reduces lever pressing.[2]

Synonyms	HDSF, Hexadecanesulfonyl fluoride
Molecular Weight	308.5
Formula	C16H33FO2S
CAS No.	86855-26-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (291.7 mM), Sonication is recommended.

References and Literature

1. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997;231(1):217-221. 2. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004;74(8):1001-1011.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

ARN272 JP104 JNJ-1661010 N-(3-Methoxybenzyl)Palmitamide PDP-EA N-Benzylpalmitamide AA38-3 URB-597

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AM 374 86855-26-7 Metabolism Neuroscience FAAH AM374 HDSF Hexadecanesulfonyl Fluoride AM-374 Hexadecanesulfonyl fluoride inhibitor inhibit

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