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AEM1

Catalog No. T8979 CAS 1030123-90-0

AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.

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AEM1, CAS 1030123-90-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 84.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 313.00
100 mg	In stock	$ 537.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 97.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	379.41
Formula	C20H14FN3O2S
CAS No.	1030123-90-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (79.07 mM)

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Obesity Compound Library Bioactive Compounds Library Max Antioxidant Compound Library Oxidation-Reduction Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Transcription Factor-Targeted Compound Library NO PAINS Compound Library Ferroptosis Compound Library

Related Products

Related compounds with same targets

Nrf2 activator-1 Antroquinonol Eriodictyol-7-O-glucoside Pyridoxine hydrochloride Resveratrol Dehydroglyasperin C Zederone KI696 isomer

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AEM1 1030123-90-0 Immunology/Inflammation Nrf2 AEM-1 inhibit Inhibitor Keap1-Nrf2 AEM 1 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.