Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 35.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 93.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 393.00 | |
100 mg | In stock | $ 576.00 |
Description | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
In vitro | 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-Aminocamptothecin cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-Aminocamptothecin concentrations exceed a threshold of 2.7 nM [2]. |
In vivo | 9-Aminocamptothecin inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-Aminocamptothecin induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
Source |
Synonyms | Aminocamptothecin, 9-amino-2(S)-camptothecin, 9-Aminocamptothecin |
Molecular Weight | 363.37 |
Formula | C20H17N3O4 |
CAS No. | 91421-43-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.33 mg/mL (9.16 mM)
You can also refer to dose conversion for different animals. More
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9-amino-CPT 91421-43-1 DNA Damage/DNA Repair Topoisomerase Inhibitor 9 amino CPT inhibit 9aminoCPT Aminocamptothecin 9-amino-2(S)-camptothecin 9-amino-2camptothecin 9-Aminocamptothecin inhibitor