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8-Azahypoxanthine

Catalog No. T20102 CAS 2683-90-1

Synonyms: 阿扎次黄嘌呤, NSC22709, NSC 22709, NSC-22709

8-Azahypoxanthine inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.

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8-Azahypoxanthine, CAS 2683-90-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	8-Azahypoxanthine inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.
In vitro	8-Azahypoxanthine has a slight radiosensitizing effect on haemopoietic stem cells and leucotic cells[1].

Synonyms	阿扎次黄嘌呤, NSC22709, NSC 22709, NSC-22709
Molecular Weight	139.12
Formula	C4H5N5O
CAS No.	2683-90-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/ml (401.17 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Volchkov VA, Mikhaĭlova NIa. Radiomodifitsiruiushchee deĭstvie 8-azagipoksantina [Radiomodifying action of 8-azahypoxanthine]. Radiobiologiia. 1984 Jan-Feb;24(1):90-2. Russian. 2. Keough DT, et al. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. J Med Chem. 2006 Dec 14;49(25):7479-86. 3. Moore BC, Leigh JA. Markerless mutagenesis in Methanococcus maripaludis demonstrates roles for alanine dehydrogenase, alanine racemase, and alanine permease. J Bacteriol. 2005 Feb;187(3):972-9. 4. Groom J, et al. Promiscuous plasmid replication in thermophiles: Use of a novel hyperthermophilic replicon for genetic manipulation of Clostridium thermocellum at its optimum growth temperature. Metab Eng Commun. 2016 Jan 29;3:30-38.

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Sapacitabine Ethynylcytidine Adenosine 5'-monophosphate disodium salt GS-443902 2'-Deoxy-2'-fluorocytidine 2′-Deoxy-2′-fluoroguanosine N6-Methyladenine 1-Methylinosine

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

8-Azahypoxanthine 2683-90-1 DNA损伤和修复细胞周期 Nucleoside Antimetabolite/Analog NSC-22709 NSC22709 NSC 22709 8 Azahypoxanthine 8Azahypoxanthine Inhibitor inhibitor inhibit

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