Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | Inquiry | $ 243.00 |
Description | 6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases. |
In vitro | 6,4'-Dihydroxy-7-methoxyflavanone showed inhibition of osteoclasts differentiation and function. 6,4'-Dihydroxy-7-methoxyflavanone increased cellular resistance to oxidative injury caused by glutamate-induced cytotoxicity in HT22 cells, via JUN N-terminal kinase (JNK) pathway dependent (HO)-1 expression. 6,4'-Dihydroxy-7-methoxyflavanone suppressed the lipopolysaccharide (LPS)-induced expression of pro-inflammatory enzymes and inflammatory mediators in BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone suppressed production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression. CONCLUSIONS: This study indicates that 6,4'-Dihydroxy-7-methoxyflavanone effectively modulates the regulation of anti-oxidative and anti-inflammatory action, via up-regulation of HO-1 in HT22 cells and BV2 microglia. 6,4'-Dihydroxy-7-methoxyflavanone possesses therapeutic potentials against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation[1]. |
Molecular Weight | 286.28 |
Formula | C16H14O5 |
CAS No. | 189689-32-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 Apoptosis Autophagy GPCR/G Protein Immunology/Inflammation MAPK NF-Κb oxidation-reduction Prostaglandin Receptor JNK NF-κB TNF ERK Antioxidant IL Receptor 6,4'Dihydroxy7methoxyflavanone 6,4' Dihydroxy 7 methoxyflavanone inhibitor inhibit