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4-Hydroxyderricin

4-Hydroxyderricin
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Purity:97.02%
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4-Hydroxyderricin

Catalog No. T10146Cas No. 55912-03-3
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
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Pack SizePriceAvailabilityQuantity
1 mg$122In Stock
5 mg$298In Stock
10 mg$447In Stock
25 mg$738In Stock
50 mg Inquiry In Stock
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Product Introduction

Bioactivity
Description
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
In vitro
4-Hydroxyderricin (100 microM) inhibited DNA synthesis in LLC cells, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs.
4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice.[2]
In vivo
4-Hydroxyderricin (50 mg/kg x 2/day; oral) inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation.[2]
4-Hydroxyderricin (10 to 100 microM) inhibited Matrigel-induced formation of capillary-like tubes by HUVECs.[2]
The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin.[2]
Chemical Properties
Molecular Weight338.4
FormulaC21H22O4
Cas No.55912-03-3
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90.0 mg/mL (266.0 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9551 mL14.7754 mL29.5508 mL147.7541 mL
5 mM0.5910 mL2.9551 mL5.9102 mL29.5508 mL
10 mM0.2955 mL1.4775 mL2.9551 mL14.7754 mL
20 mM0.1478 mL0.7388 mL1.4775 mL7.3877 mL
50 mM0.0591 mL0.2955 mL0.5910 mL2.9551 mL
100 mM0.0296 mL0.1478 mL0.2955 mL1.4775 mL

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