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3,4 Dichloroisocoumarin
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Catalog No. T8677Cas No. 51050-59-0
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
3,4 Dichloroisocoumarin
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Purity: 97.94%
Catalog No. T8677Cas No. 51050-59-0
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $155 | In Stock | In Stock | |
| 25 mg | $262 | In Stock | In Stock | |
| 50 mg | $389 | In Stock | In Stock | |
| 100 mg | $573 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $87 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.94%
Appearance:Solid
Color:White
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Product Introduction
3,4 Dichloroisocoumarin AI Summary
3,4 Dichloroisocoumarin shows a broad range of bioactivities, demonstrating its potential across various therapeutic areas. It functions as an inhibitor of elastase enzymes, including human leukocyte elastase with an IC50 of 100.0 nM, rat leukocyte elastase with an IC50 of 700.0 nM, and pancreatitic porcine elastase with an IC50 of 800.0 nM. Additionally, it inhibits various blood coagulation factors like bovine thrombin, human thrombin, and porcine factor IXa with differing binding affinities. Its enzymatic inhibition extends to targets such as prodrug hydrolase, recombinant CatA, human PBMC extract prodrug hydrolase, and cathepsin G, exhibiting IC50 values from 500.0 nM to 93000.0 nM. The compound also impedes Toxoplasma gondii 2F1 invasion in HFF cells with an IC50 of 12500.0 nM and shows antiplasmodial activity against Plasmodium falciparum W2 with an IC50 of 15848.93 nM. Further, it disrupts various cellular pathways including NFkB signaling, mitochondrial function, and protein splicing, and targets enzymes such as Cytochrome P450 and ALDH1A1. 3,4 Dichloroisocoumarin exhibits antiviral potential by inhibiting Lassa Virus and Marburg Virus entry into cells and is also noted for its reversible inhibition of Escherichia coli rhomboid GlpG. Thus, 3,4 Dichloroisocoumarin presents significant bioactivity across multiple biological targets, indicating its versatility and potential for therapeutic development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor |
| Molecular Weight | 215.03 |
| Formula | C9H4Cl2O2 |
| Cas No. | 51050-59-0 |
| Smiles | Clc1oc(=O)c2ccccc2c1Cl |
| Relative Density. | 1.53 g/cm3 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.16 mg/mL (10.05 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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