Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 63.00 | |
2 mg | In stock | $ 90.00 | |
5 mg | In stock | $ 161.00 | |
10 mg | In stock | $ 283.00 | |
25 mg | In stock | $ 583.00 | |
50 mg | In stock | $ 833.00 | |
100 mg | In stock | $ 1,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 171.00 |
Description | 2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer. |
In vitro | 2OH-BNPP1 disrupts TGFβ signaling by hindering the phosphorylation of key proteins involved in both the canonical and non-canonical TGFβ pathways across a variety of cancerous and normal cell lines in a dose-dependent manner[1]. At concentrations ranging from 0.1 to 50 μM, it effectively suppresses TGFβ signaling in a dose-dependent fashion. |
In vivo | 2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo as well as significantly decreases the abundance of phosphorylated SMAD2 in tumor-bearing mice[1]. |
Molecular Weight | 297.36 |
Formula | C16H19N5O |
CAS No. | 833481-73-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥ 100 mg/mL (336.30 mM)
You can also refer to dose conversion for different animals. More
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2OH-BNPP1 833481-73-5 Others inhibit 2OH BNPP1 2OH-BNPP-1 Inhibitor 2OHBNPP1 inhibitor