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2-(Methylamino)-1H-purin-6(7H)-one

Catalog No. T13791 CAS 10030-78-1

Synonyms: N2-methylguanine

2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.

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2-(Methylamino)-1H-purin-6(7H)-one, CAS 10030-78-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 392.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 852.00

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Purity: 98.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.

In vitro

2-(Methylamino)-1H-purin-6(7H)-one is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[1]. 2-(Methylamino)-1H-purin-6(7H)-one is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[2].

Synonyms	N2-methylguanine
Molecular Weight	165.15
Formula	C6H7N5O
CAS No.	10030-78-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3751-4. 2. Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15;26(16):3640-4.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Anti-Tumor Natural Product Library Human Metabolite Library Natural Product Library Anti-infective Natural Product Library Natural Product Library for HTS Anti-Cancer Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Bioactive Compound Library

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Keywords

2-(Methylamino)-1H-purin-6(7H)-one 10030-78-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology Antibacterial DNA/RNA Synthesis Endogenous Metabolite Inhibitor Bacterial 2 (Methylamino) 1H purin 6(7H) one 2(Methylamino)1Hpurin6(7H)one N2-methylguanine inhibit inhibitor

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