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1,3,7-Trimethyluric acid

Name: 1,3,7-Trimethyluric acid
Brand: TargetMol
SKU: T19792
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19792Cas No. 5415-44-1

1,3,7-Trimethyluric acid, a purine alkaloid, occurs as a minor metabolite of caffeine in humans. It functions as an antioxidant with the ability to scavenge hydroxyl radicals and offers protective benefits against lipid peroxidation in erythrocyte membranes.

1,3,7-Trimethyluric acid

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Purity: 99.96%

Catalog No. T19792Cas No. 5415-44-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$46	In Stock	In Stock
50 mg	$67	In Stock	In Stock
100 mg	$97	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

1,3,7-Trimethyluric acid AI Summary

1,3,7-Trimethyluric acid inhibits Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase, with IC50 values of 70000.0 nM in the presence of NH4Cl and 67000.0 nM in the presence of L-glutamine/GTP. Additionally, it exhibits diverse bioactivities: it acts as a potent inhibitor of BAZ2B with an IC50 of 707.9 nM, inhibits Polymerase Iota with an IC50 of 112201.8 nM, blocks binding or entry into cells for Marburg Virus with an IC50 of 8196.1 nM, inhibits Hepatitis C Virus (HCV) with an IC50 of 4466.8 nM, and functions as an agonist of the gsp gene related to Fibrous Dysplasia/McCune-Albright Syndrome with an IC50 of 25118.9 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	210.19
Formula	C₈H₁₀N₄O₃
Cas No.	5415-44-1
Smiles	CN1C(O)=NC2=C1C(=O)N(C)C(=O)N2C
Relative Density.	1.55g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (23.79 mM), Sonication is recommended.

DMSO: 13.89 mg/mL (66.08 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7576 mL	23.7880 mL	47.5760 mL	237.8800 mL
5 mM	0.9515 mL	4.7576 mL	9.5152 mL	47.5760 mL
10 mM	0.4758 mL	2.3788 mL	4.7576 mL	23.7880 mL
20 mM	0.2379 mL	1.1894 mL	2.3788 mL	11.8940 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0952 mL	0.4758 mL	0.9515 mL	4.7576 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc