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1,3,6-Tri-O-galloyl-beta-D-glucose

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Catalog No. TN1166Cas No. 18483-17-5
Alias 1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucose

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

1,3,6-Tri-O-galloyl-beta-D-glucose

1,3,6-Tri-O-galloyl-beta-D-glucose

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🥰Excellent
Purity: 99.47%
Catalog No. TN1166Alias 1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucoseCas No. 18483-17-5
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$118In StockIn Stock
5 mg$291In StockIn Stock
10 mg$432In StockIn Stock
25 mg$716In StockIn Stock
50 mg$987In StockIn Stock
1 mL x 10 mM (in DMSO)$396In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.47%
Appearance:Solid
Color:White to Yellow
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
In vitro
The compounds were isolated by silica gel column chromatography, Sephadex LH-20 column chromatography and ODS column chromatography.Their structures were elucidated by spectral analyses and physicochemical properties. The anti-inflammatory activities of selected isolated compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cell lines by Griess reaction. Eight compounds were obtained from n-butanol fraction oi Mangifera indica L. seed kernel, whose structures were elucidated as 4-O-ethylgallic acid (1), gallic acid (2), citric acid(3), 1,2,3,4,6-penta-O-galloylglucose(4),1,3,6-Tri-O-galloylglucose(5), hyperoside(6), quercetin-3-O-rhamnopyranoside(7), and mangiferin(8). Compounds 1, 2 and 4-8 exhibited potent inhibitory effect on NO production in LPS-induced macrophages, especially compounds 6 and 8 showed the best inhibitory activity with IC50 values of 16.5 and 19.5 μmol·L-1, respectively.
Synonyms1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucose
Chemical Properties
Molecular Weight636.47
FormulaC27H24O18
Cas No.18483-17-5
SmilesO[C@@H]1[C@@H](COC(=O)c2cc(O)c(O)c(O)c2)O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Relative Density.1.98 g/cm3
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 1 mg/mL (1.57 mM), Sonication and heating are recommended.
DMSO: 100 mg/mL (157.12 mM), Sonication and heating are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.18 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5712 mL7.8558 mL15.7117 mL78.5583 mL
DMSO
1mg5mg10mg50mg
5 mM0.3142 mL1.5712 mL3.1423 mL15.7117 mL
10 mM0.1571 mL0.7856 mL1.5712 mL7.8558 mL
20 mM0.0786 mL0.3928 mL0.7856 mL3.9279 mL
50 mM0.0314 mL0.1571 mL0.3142 mL1.5712 mL
100 mM0.0157 mL0.0786 mL0.1571 mL0.7856 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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