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(R)-Equol

Catalog No. T13443 CAS 221054-79-1

Synonyms: (+)-Equol

(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.

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(R)-Equol, CAS 221054-79-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 57.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 162.00
50 mg	In stock	$ 238.00
100 mg	In stock	$ 358.00
200 mg	In stock	$ 528.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
Targets&IC50	ERβ:15.4 nM (Ki), ERα:27.4 nM (Ki)
In vitro	(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2].
In vivo	In Animals, (R)-Equol has a significantly reduced number of palpable tumors over time when compared with Controls (P=0.002).In addition, the number of palpable tumors formed by each rat in the (R)-Equol fed group was significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animals is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003) [3].

Synonyms	(+)-Equol
Molecular Weight	242.27
Formula	C15H14O3
CAS No.	221054-79-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (412.76 mM), Sonification and heating are recommended.

References and Literature

1. Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9. 2. Magee PJ, et al. Daidzein, R-(+)equol and S-(-)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2. Eur J Nutr. 2014 Feb;53(1):345-50. 3. Brown NM, et al. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer. Carcinogenesis. 2010 May;31(5):886-93.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Human Metabolite Library Nuclear Receptor Compound Library Endocrinology-Hormone Compound Library

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Keywords

(R)-Equol 221054-79-1 Endocrinology/Hormones Estrogen/progestogen Receptor (+)-Equol (R) Equol Equol (R)Equol Inhibitor Estrogen Receptor/ERR inhibit inhibitor

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