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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T8468 CIL62 117593-36-9 97.74%
CIL62
CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].
T8296 5,​7,​4'-​Trimethoxyflavone 5631-70-9 97.53%
5,​7,​4'-​Trimethoxyflavone
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
T36347 Ac-YVAD-CMK 178603-78-6 97.08%
Ac-YVAD-CMK
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprot...
TN2097 Pomolic acid 13849-91-7 96.84%
Pomolic acid
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
TN1405 Arnicolide D 34532-68-8 96.66%
Arnicolide D
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T2881 Crustecdysone 5289-74-7 96.31%
Crustecdysone
Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.
TN2175 Salvianolic acid F 158732-59-3 96.01%
Salvianolic acid F
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentratio...
T36534 SDZ 224-015 161511-45-1 95.49%
SDZ 224-015
SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1.SDZ 224-015 exhibits anti-COVID-19 and anti-inflammatory acti...
T36819 Ac-FLTD-CMK 2376255-48-8 95.17%
Ac-FLTD-CMK
Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects o...
T7374 2-HBA 131359-24-5 95.01%
2-HBA
2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
T3519 Formosanin C 50773-42-7 100%
Formosanin C
Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and...
T0282 Q-VD-OPH 1135695-98-5 100%
Q-VD-OPH
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a pan-caspase inhibitor with potent antiapoptotic properties.
T6013 Z-VAD(OMe)-FMK 187389-52-2
Z-VAD(OMe)-FMK
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a broad-spectrum inhibitor of caspases that is cell-permeable and irreversible. Z-VAD(OMe)-FMK binds to activated casp...
T10580 BOC-D-FMK 634911-80-1
BOC-D-FMK
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).
T3907 Tenuigenin 2469-34-3
Tenuigenin
Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
TN3967 Epieriocalyxin A 191545-24-1
Epieriocalyxin A
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
T8092 Taurohyodeoxycholic acid sodium salt 38411-85-7
Taurohyodeoxycholic acid sodium salt
Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase...
T3123 Allicin 539-86-6
Allicin
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
T78631 Ac-YVAD-AOM 154674-81-4 98%
Ac-YVAD-AOM
Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.
T83653 SACLAC 2248703-42-4 98%
SACLAC
SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML ...
CIL62
T8468
CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].
5,​7,​4'-​Trimethoxyflavone
T8296
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
Ac-YVAD-CMK
T36347
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprot...
Pomolic acid
TN2097
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediat...
Arnicolide D
TN1405
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
Crustecdysone
T2881
Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.
Salvianolic acid F
TN2175
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentratio...
SDZ 224-015
T36534
SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1.SDZ 224-015 exhibits anti-COVID-19 and anti-inflammatory acti...
Ac-FLTD-CMK
T36819
Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects o...
2-HBA
T7374
2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
Formosanin C
T3519
Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and...
Q-VD-OPH
T0282
Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a pan-caspase inhibitor with potent antiapoptotic properties.
Z-VAD(OMe)-FMK
T6013
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a broad-spectrum inhibitor of caspases that is cell-permeable and irreversible. Z-VAD(OMe)-FMK binds to activated casp...
BOC-D-FMK
T10580
Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 µM).
Tenuigenin
T3907
Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.
Epieriocalyxin A
TN3967
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
Taurohyodeoxycholic acid sodium salt
T8092
Taurohyodeoxycholic acid sodium salt (Sodium taurohyodeoxycholate hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase...
Allicin
T3123
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
Ac-YVAD-AOM
T78631
Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity.
SACLAC
T83653
SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML ...
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