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Formosanin C

Catalog No. T3519 CAS 50773-42-7

Synonyms: Polyphyllin B

Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems.

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Formosanin C, CAS 50773-42-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 228.00

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Purity: 100%

Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems.
In vitro	Attenuation of formosanin C-induced change of Deltapsi(m) by caspase-2 inhibitor (Z-VDVAC) implies that caspase-2 acts upstream of the mitochondria. Blockage of formosanin C-induced apoptotic process by using either permeability transition pore inhibitor (cyclosporine A) or caspase-9 inhibitor (Z-LEHD) demonstrates the necessity of mitochondria and caspase-9 in formosanin C-induced apoptosis of HT-29 cells.
Kinase Assay	The enzyme activity and kinetics of the purified ROCK1(3-543) are determined using scintillation proximity assay. In this assay, purified ROCK1 is incubated with peptide substrate (Biotin-Ahx-AKRRLSSLRA-CONH2), and 33ATP and the subsequent incorporation of 33P into the peptide is quantified by streptavidin bead capture. For IC50 determination, test compounds are dissolved at 10 mM in 100% DMSO, with subsequent serial dilution in 100% DMSO. Compounds are typically assayed over an 11-point dilution range with a concentration in the assay of 10 μM to 0.2 nM in 3-fold dilutions. For dose-response curves, data are normalized and expressed as percentage inhibition using the formula 100×[(U-C1)/(C2-C1)], where U is the unknown value, C1 is the average of the high signal (0%) control wells, and C2 is the average of the low signal (100%) control wells. Curve fitting is performed The results for each compound are recorded as pIC50 values[1].
Source	Natural Products > Liliaceae > Paris

Synonyms	Polyphyllin B
Molecular Weight	1015.18
Formula	C51H82O20
CAS No.	50773-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (27.09 mM)

References and Literature

1. Lee JC., et al. Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 2009 Mar;100(3):503-13.

Citations

1. Chen P, Wu S, Dong X, et al. Formosanin C induces autophagy-mediated apoptosis in multiple myeloma cells through the PI3K/AKT/mTOR signaling pathway. Hematology. 2022, 27(1): 977-986

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library Anti-Cancer Active Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Protease Inhibitor Library Anti-Cancer Compound Library Traditional Chinese Medicine Monomer Library Immunology/Inflammation Compound Library Bioactive Compound Library

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Keywords

Formosanin C 50773-42-7 Apoptosis Proteases/Proteasome Caspase Polyphyllin B inhibit Inhibitor inhibitor

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