κ-opioid — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9459	GR103545		Others
	GR103545 is a selective agonist of the κ-opioid receptor, which is a radiotracer that can be used as in vivo imaging.		Others
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
T4691	Asimadoline hydrochloride	EMD-61753 hydrochloride	Opioid Receptor
	Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s...		Opioid Receptor
T4633	Asimadoline	EMD-61753	Opioid Receptor
	Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline...		Opioid Receptor
TQ0091	LY2795050		Opioid Receptor
	LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).		Opioid Receptor
T6175	ADL-5859	ADL5859 Hydrochloride,ADL5859 HCl	Opioid Receptor
	ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.		Opioid Receptor
T5167	Cebranopadol	GRT6005	Opioid Receptor
	Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor, respectively.		Opioid Receptor
T23306	Salvinorin A		Opioid Receptor
	Salvinorin A is a non-nitrogenous κ-opioid selective agonist.		Opioid Receptor
T12241	Norbinaltorphimine dihydrochloride	nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride	Opioid Receptor
	Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.		Opioid Receptor
TP2322L	Beta-Neoendorphin acetate(77739-21-0 free base)		Opioid Receptor
	beta-Neoendorphin acetate is an agonist of κ-opioid receptor		Opioid Receptor
T22849	ICI 199,441 hydrochloride		Opioid Receptor
	ICI 199,441 hydrochloride is a potent, selective agonist of κ-opioid receptor.		Opioid Receptor
T22850	ICI 204,448	ICI 204448,ICI204448,ICI-204448	Opioid Receptor
	ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases.		Opioid Receptor
TP1826L	Dynorphin B (1-13) acetate(83335-41-5 free base)		Opioid Receptor
	Dynorphin B (1-13) acetate acts as an agonist on opioid κ-receptor.		Opioid Receptor
T67888L	Samidorphan HCl	Samidorphan HCl（852626-89-2 free base）	Opioid Receptor
	Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonis...		Opioid Receptor
TP1813L	Dynorphin A 1-10 acetate(79994-24-4 free base)		Opioid Receptor
	Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.		Opioid Receptor
TP2105L	UFP-101 acetate	UFP-101 acetate(849024-68-6 free base)	Opioid Receptor
	UFP-101 acetate is a selective and competitive antagonist of the NOP receptor (pKi = 10.24) with >3000-fold selectivity over δ, μ, and κ opioid receptors.		Opioid Receptor
T14835	BTRX-335140	CYM-53093	Opioid Receptor
	BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140...		Opioid Receptor
T6553	JTC-801	JTC 801,JTC801	Opioid Receptor
	JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ.		Opioid Receptor
T76341L	[DPro10] Dynorphin A (1-11)acetate,porcine	[DPro10] Dynorphin A (1-11)acetate,porcine(94596-26-6 Free base)	Opioid Receptor
	[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity.		Opioid Receptor
T39988	6'-GNTI dihydrochloride		Opioid Receptor , Akt
	6'-GNTI dihydrochloride is a κ-opioid receptor (KOR) agonist that favors activation of G-protein-mediated signaling over recruitment of β-aspirin 2. 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neur...		Opioid Receptor , Akt