tetrodotoxin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7502L	PF 05089771	PF-05089771,PF05089771	Sodium Channel
	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.		Sodium Channel
T7502	PF 05089771 tosylate		Sodium Channel
	PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...		Sodium Channel
T2024	A-803467	A 803467,A803467	Sodium Channel
	A-803467 is a selective NaV1.8 channel blocker.		Sodium Channel
T37093	4,9-Anhydrotetrodotoxin	4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX
	4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrate...
T4S1876	3-Deoxyaconitine		Sodium Channel
	3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...		Sodium Channel
T28227	Oe-9000	Oe 9000
	Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-r...
T80428	Jingzhaotoxin-34		Sodium Channel
	Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neurons with an IC50 of approximately 85 nM and exerts negligible inf...		Sodium Channel
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle...
T80426	Jingzhaotoxin-IX		Sodium Channel
	Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms of voltage-gated sodium channels, as well a...		Sodium Channel
T80186	Hainantoxin-III		Sodium Channel
	Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting both tetrodotoxin-resistant and tetrodotoxin-sensitive sodium curren...		Sodium Channel
T80425	Jingzhaotoxin-V		Sodium Channel
	Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons, with IC50 val...		Sodium Channel
T80488	µ-Conotoxin SIIIA		Sodium Channel
	μ-Conotoxin SIIIA, a tetrodotoxin (TTX)-resistant sodium channel blocker, is a toxic peptide derived from Conus snail venom. It has applications in researching neurological diseases, including neuropathic pain [1].		Sodium Channel
T80851	VSTx-3	Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3 is a potassium voltage-gated channel (K_V) blocker, which has also been shown to be a potent tetrodotoxin-sensitive (TTX-sensitive) sodium channel inhibitor, with particular efficacy against NaV1.8 channels, as ev...
T80495	MHuwentoxin-IV		Sodium Channel
	mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in dorsal root ganglion neurons with an IC50 value of 54.16 nM. Notably, the i...		Sodium Channel
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action ...
T80189	Hainantoxin-IV	HNTX-IV	Sodium Channel
	Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for binding to the target. This compound also features an inhibi...		Sodium Channel
TN4183	Hardwickiic acid	(-)-Hardwikiic acid	Sodium Channel
	Hardwickiic acid ((-)-Hardwikiic acid) is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. h...		Sodium Channel