state-dependent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22675	Co 102862	V 102862	Others , Sodium Channel
	Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.		Others , Sodium Channel
T8711	PF-05186462	PF-05150122	Sodium Channel
	PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.		Sodium Channel
T33816	Ordopidine	ACR-325,ACR 325,ACR325	Dopamine Receptor
	Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and...		Dopamine Receptor
T14884	CBR-5884		Others , Dehydrogenase
	CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with h...		Others , Dehydrogenase
T24902	TROX-1	TROX1,TROX 1
	TROX-1 is the activation state-dependent Cav2 channel antagonist.
T14992	Raxatrigine hydrochloride	GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)	Others
	Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.		Others
T71239	CNV-2197944
	CNV-2197944 is a novel, small molecule, state-dependent calcium channel blocker, designed to selectively inhibit highly active Cav2.2 channels.
TN2830	26-Nor-8-oxo-alpha-onocerin		Others
	26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.		Others
T7352L	Pridopidine hydrochloride	ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride
	Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor ...
TN3844	Didrovaltrate		Calcium Channel
	Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascu...		Calcium Channel
T23652	AFD-21	AFD21,NS-2 Class 1 antiarrhythmic agent
	AFD-21 is a class I antiarrhythmic drug. It binds to sodium channels in their inactivated state and exerts use- and voltage-dependent inhibition of sodium channels with unbinding rates comparable to those of class I anti...
T79280	Nav1.3 channel inhibitor 1		Sodium Channel
	Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM. It has the ability to cross the blood-brain barrier, making it applicabl...		Sodium Channel
T70004	APS-2-79
	APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes ...
T35946	17(R)-Resolvin D1	Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response ...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits...