sickness — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2112	Fexinidazole	HOE 239	Others , Parasite
	Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica...		Others , Parasite
T1110	Meclizine dihydrochloride	Meclozine dihydrochloride,NSC28728,Meclizine 2HCl	Apoptosis , Histamine Receptor
	Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.		Apoptosis , Histamine Receptor
T7641	5-Hydroxytryptophol		Endogenous Metabolite
	5-Hydroxytryptophol is a metabolite of tryptophan. It is used as a biomarker for recent alcohol consumption and causes sleeping sickness		Endogenous Metabolite
T21281	Zolamide	CL 5343,Tio-urasin,5-Amino-TDSNH2	Others
	Zolamide (CL 5343) may be used to prevent altitude sickness and reduce the symptoms.		Others
TN3497	Benzylamine hydrochloride		Others
	Benzylamine hydrochloride, made of benzylamine and hydrochloric acid, is used to treat motion sickness and ascariasis, with antiemesis properties.		Others
T60351	Acetazolamide sodium	OT-302 sodium	Carbonic Anhydrase
	Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and alt...		Carbonic Anhydrase
T3282	Alimemazine hemitartrate	Alimemazine Tartrate,Methylpromazine Tartrate,Trimeprazine tartrate,Trimeprazine hemitartrate	Others
	Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.		Others
T3O2784	Vitamin B6		Others
	Vitamin B6 is a component of some coenzymes in human body, which is involved in a variety of metabolic reactions, especially related to amino acid metabolism.Clinical application of vitamin B6 in the prevention and treat...		Others
T40652	Meclizine	Meclozine	Histamine Receptor
	Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ...		Histamine Receptor
T33278	Melarsoprol	Melarsoprolum,RP 3854,RP3854,RP-3854
	Melarsoprol, an organoarsenic compound, can be used to treat trypanosomiasis (human African sleeping sickness).
T71685	NEU-1953
	NEU-1953 is a potential candidate for sleeping sickness.
T28011	Megazol	CL 64855,CL-64855,CL64855
	Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping si...
T61635	HCAI/II-IN-4
	hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. ...
T61832	HCAI/II-IN-3
	hCAI/II-IN-3 (compound 5b) is a highly effective dual inhibitor of hCA I/II enzymes. It exhibits Ki values of 51.25, 13.15, and 42.18 nM for hCA I, hCA II, and hCA Ⅸ, respectively. hCAI/II-IN-3 demonstrates anti-hypoxic ...
T69012	Cinnarizine clofibrate
	Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion si...
T61282	HCAI/II-IN-2
	hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its an...
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the pr...