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Search Results for " spla2 "

20

Compounds

Cat No. Product Name Synonyms Targets
T12990 sPLA2-X Inhibitor 31 Others
sPLA2-X Inhibitor 31 is a selective inhibitor of secreted phospholipase A2 type X (sPLA2-X) (IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively).
T27731 sPLA2 inhibitor 1 KH-064,KH 064,KH064,5-BPP acid
KH064 is a sPLA2-IIA inhibitor of oral activity.
T81115 sPLA2-IIA Inhibitor
The sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK, specifically cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2), which interacts with human IIA phospholipase A2 (hGIIA) to impede its ester bond hydrolyzing function. A...
T13206 Tris(2,4-di-tert-butylphenyl)phosphate Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is a natural compound isolated from Vitex negundo L. with anti-inflammatory activity.
T2044 Varespladib LY315920 Phospholipase
Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusiv...
T2907 Tanshinone I Tanshinone A Phospholipase
Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
T39173 Varespladib sodium LY315920 sodium
Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in seru...
T22950 LY-311727 LY 311727 Others
secreted phospholipase A2 (sPLA2) inhibitor
T23547 YM 26734 Others
Competitive inhibitor of secretory phospholipase A2 (sPLA2)
T25787 Me-Indoxam Methyl indoxam,Methyl-indoxam
Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis.
T37580 Arachidonoyl thio-PC
Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagen...
T61168 CAY10590
CAY10590 (GK115) is a compound that functions as an inhibitor of secreted phospholipase A2 (sPLA2). It is commonly employed in research related to chronic inflammatory kidney diseases [1].
T30831 Cgp 43182 Cgp-43182,Cgp43182
CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines media...
T75589 Bitis Cornuta Venom
Bitis Cornuta (Many-horned Adder) Venom, sourced from Bitis Cornuta, comprises snake venom phospholipase A2 (sPLA2) toxins that exhibit anticoagulant properties by inhibiting the prothrombinase complex, consequently prom...
T37221 GK187
GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assa...
T37123 1,2-Dioctanoyl PC
Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fat...
T37244 Palmitoyl thio-PC
Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrat...
T37785 1-Palmitoyl-2-linoleoyl PE
Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in...
T10168 5-HT1A modulator 1 5-HT1Amodulator1 Phospholipase , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).
T35622 FKGK 18
FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA...
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TargetMol