17
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23450 | TCS PrP Inhibitor 13 | 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One | Others |
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. | |||
T4578 | Tipranavir | PNU-140690 | SARS-CoV , HIV Protease |
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple... | |||
T4547 | Grazoprevir | MK-5172 | HCV Protease , SARS-CoV |
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ... | |||
T28811 | SM111 | SM 111,SM-111 | |
SM111 inhibits in vitro replication of HIV-1, including strains resistant to reverse transcriptase, licensed protease, and integrase inhibitors, without major cellular toxicity. | |||
T12065 | Grazoprevir sodium salt | MK-5172 (sodium salt) | Others |
Grazoprevir sodium salt is a selective Hepatitis C virus NS3/4a protease inhibitor with broad activity across genotypes and resistant variants. | |||
T64112 | HIV-1 protease-IN-5 | ||
HIV-1 protease-IN-5 is an HIV-1 protease inhibitor (IC50: 1.64 nM). HIV-1 protease-IN-5 exhibits significant effects on wild-type and DRV-resistant HIV-1. | |||
T21456 | Grazoprevir hydrate | Grazoprevir,MK5172,MK 5172,MK-5172 | |
Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to ... | |||
T30924 | CI-1029 | CI1029,PD 178390,UNII-VDH375TRL9,PD178390 | |
CI-1029 is an HIV protease inhibitor that is effective against mutant HIV proteases and drug-resistant HIV strains. It has excellent protease activity, good antiviral efficacy in cell tests, and has good bioavailability ... | |||
T63949 | HIV-1 protease-IN-2 | ||
HIV-1 protease-IN-2 is a potent inhibitor of HIV-1 protease (IC50: 2.53 nM). HIV-1 protease-IN-2 exhibits antiviral effects against DRV (Darunavir) sensitive or drug resistant HIV-1 mutants. | |||
T71006 | BI-1388 | ||
BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K. | |||
T79537 | HIV-1 protease-IN-12 | HIV Protease | |
HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-resistant variant [1]. | |||
T79536 | HIV-1 protease-IN-11 | HIV Protease | |
HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy against drug-resistant variant [1]. | |||
T63733 | HIV-1 protease-IN-6 | ||
HIV-1 protease-IN-6 (compound 17d) is a potent inhibitor of HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM). HIV-1 protease-IN-6 showed significant antiviral activity against DRV (darunavir) resistant mutants, even exceeding th... | |||
T26574 | AG-7404 | AG 7404 | |
AG-7404 is a potent protease inhibitor with anti-poliovirus activity. AG-7404 was active against all virus with EC50 values ranging from 0.080 to 0.674 μM. AG-7404 was fully active against V-073-resistant variants with E... | |||
T79277 | Cysteine protease inhibitor-3 | Parasite | |
Cysteine protease inhibitor-3 (Compound 15), a cysteine protease inhibitor, exhibits anti-plasmodial activity, effectively inhibiting Pf3D7 (IC50 = 0.74 μM), PfW2 (IC50 = 1.05 μM), PfFP2 (IC50 = 3.5 μM), and PfFP3 (IC50 ... | |||
T78950 | HIV-1 protease-IN-8 | HIV Protease | |
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a dru... | |||
T35674 | StRIP16 | ||
Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system. Cromm et al (2016) Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase. ACS ... |