polymorphonuclear — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride	Leu-Leu-ome hydrochloride	Others , Endogenous Metabolite
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) is a lysosomal condensation product that cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes.		Others , Endogenous Metabolite
T27026	CJ-13,610	CJ 13610,CJ-13610	Lipoxygenase
	CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.		Lipoxygenase
T22946	LY255283	LY 255283	Leukotriene Receptor
	LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A2318...		Leukotriene Receptor
T68166	Traxanox		Others
	Traxanox is an orally available diuretic.Traxanox enhances phagocytosis of yeast granules by mouse peritoneal macrophages or rat peritoneal polymorphonuclear leukocytes in vitro.Restorative effect of Traxanox on inhibiti...		Others
T36879L	H-Leu-Leu-OMe . HBr	H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others
	H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eli...		Others
T68166L	Traxanox TFA	Traxanox TFA(58712-69-9 Free base)	Others
	Traxanox TFA is an orally available diuretic. Traxanox TFA enhances phagocytosis of yeast granules by mouse peritoneal macrophages or rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox TFA restores inhibition...		Others
T4S1422	Praeruptorin E		Others , Calcium Channel
	1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...		Others , Calcium Channel
T24328	L 680833	L680,833,L680833,L-680,833,L 680,833,L-680833
	L 680833 is an orally active monocyclic beta-lactam human polymorphonuclear leukocyte elastase inhibitor.
T69110	Aseanostatin P5
	Aseanostatin P5 inhibits myeloperoxidase (MPO) release from human polymorphonuclear leukocytes.
T71025	KP 10614
	KP 10614 is a new prostacyclin analog that inhibits platelet-polymorphonuclear leukocyte interaction.
T24305	L 651142	L651,142,L651142,L-651,142,L 651,142,L-651142
	L 651142 is a weak inhibitor of the platelet-activating factor receptor. It is also binding to polymorphonuclear leukocytes.
T22526	BML-111	5(S),6(R)-7-trihydroxymethyl Heptanoate	Others
	inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis		Others
TN6057	1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
TN2552	1-Methyl-2-nonylquinolin-4(1H)-one		Others
	1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.		Others
T13716	(+)-Guaiacin		Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-act...		Others
T15825	LY 178002		Retinoid Receptor
	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays re...		Retinoid Receptor
TN4486	Magnolianin		Others
	Magnolianin can inhibit strongly (IC50 = 0.45 uM) 5-HETE formation by die cytosol of guinea pig polymorphonuclear leukocytes.		Others
TP2395	Nph-peptide
	Nph-peptide can be used for photoaffinity labeling of the N-formyl peptide receptor site of intact human polymorphonuclear leukocytes.
T27408	Gea 3162	Gea3162,Gea-3162
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
T0260L	Meclofenamate sodium hydrate	INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668
	Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free ra...