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PNU-282987

Catalog No. T2422 CAS 123464-89-1

PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).

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PNU-282987, CAS 123464-89-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 65.00
25 mg	In stock	$ 133.00
50 mg	In stock	$ 239.00
100 mg	In stock	$ 439.00
200 mg	In stock	$ 585.00
1 mL * 10 mM (in DMSO)	In stock	$ 71.00

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Purity: 100%

Purity: 99.92%

Purity: 99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
Targets&IC50	α7 nAChR (rat):26 nM(Ki)
Kinase Assay	Kinase inhibition assays : Kinase inhibition is measured by the use of radiometric assays conducted by Kinase Profiler service. Briefly, in the presence or absence of SKLB1002, VGFR2 (5–10 mU) is incubated in 25-μL reaction solution containing 8 mmol/L 3-(N-morpholino)propanesulfonic acid (MOPS), pH 7.0, 0.2 mmol/L EDTA, 0.33 mg/mL myelin basic protein, 10 mmol/L Mg acetate, and γ-[33P]ATP. After incubation for 40 minutes at room temperature, the reaction is stopped and 10 μL of the reaction solution is then spotted onto a P30 filtermat and washed 3 times for 5 minutes in 75 mmol/L phosphoric acid and once in methanol prior to scintillation counting.

Molecular Weight	301.21
Formula	C14H18Cl2N2O
CAS No.	123464-89-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 26.5 mg/mL(100 mM)

References and Literature

1. Bodnar AL, et al. J Med Chem. 2005 Feb 24;48(4):905-8.

Citations

1. Zhang T, Yang K, Chen Y, et al. Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment. Journal of Periodontal Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library Preclinical Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PNU-282987 123464-89-1 Neuroscience AChR nAChR Inhibitor PNU282987 Nicotinic acetylcholine receptors inhibit PNU 282987 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.