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Acetamiprid

Catalog No. T14094   CAS 135410-20-7

Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.

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Acetamiprid Chemical Structure
Acetamiprid, CAS 135410-20-7
Pack Size Availability Price/USD Quantity
50 mg In stock $ 41.00
100 mg In stock $ 59.00
500 mg In stock $ 143.00
1 mL * 10 mM (in DMSO) In stock $ 66.00
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Purity: 99.78%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist. Acetamiprid is a neonicotinoid insecticide used worldwide. It is shown to be associated with neuromuscular and reproductive disorders.
In vivo Acetamiprid decreases in body weight and mildly affected spermatogenesis [1]. Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats[2]. Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice[1].
Molecular Weight 222.67
Formula C10H11ClN4
CAS No. 135410-20-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 97 mg/mL (435.62mM)

TargetMolReferences and Literature

1. Terayama H, et al. Effect of acetamiprid on the immature murine testes. Int J Environ Health Res. 2018 Dec;28(6):683-696. 2. Kong D, et al. Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells. Biol Reprod. 2017 Jan 1;96(1):254-265.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Neuronal Signaling Compound Library Human Metabolite Library NO PAINS Compound Library Anti-Alzheimer's Disease Compound Library Neurotransmitter Receptor Compound Library Covalent Inhibitor Library

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Keywords

Acetamiprid 135410-20-7 Neuroscience AChR Nicotinic acetylcholine receptors spermatogenesis Neonicotinoid insecticide reproductive Inhibitor inhibit nAChR inhibitor

 

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