11
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0160 | Anagrelide | Anagrelida,Xagrid,Anagrelidum | PDE |
Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production. | |||
T4570 | Pipobroman | Vercyte,A-8103,Amedel | Others , DNA Alkylator/Crosslinker |
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... | |||
T1995 | Fedratinib | TG-101348,SAR 302503 | Apoptosis , FLT , c-RET , JAK |
Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3. | |||
T9251 | Fedratinib hydrochloride hydrate | TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate | Apoptosis , JAK |
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor. | |||
T10009 | JAK3-IN-7 | JAK | |
JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ... | |||
T71313 | BVB-808 | ||
BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative... | |||
T76853 | Ropeginterferon alfa-2b | ||
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft), a monopegylated interferon-alpha (IFN-α), is utilized in the study of myeloproliferative neoplasms [1]. | |||
T64227 | JAK2 JH2 binder-1 | ||
JAK2 JH2 binder-1 is a potent and selective JAK2 JH2 binder (Ki: 37.1 nM). JAK2 JH2 binder-1 has the potential to be used in the study of various myeloproliferative neoplasms. | |||
T79581 | JAK2-IN-9 | JAK | |
Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This com... | |||
T9634 | Bomedemstat | ||
Bomedemstat (IMG-7289) is an orally active and irreversible inhibitor of the epigenetically active lysine-specific demethylase 1 (LSD1) in mouse models of myeloproliferative neoplasms (MPNs). Bomedemstat shows antineopla... | |||
T73567 | ZT55 | ||
ZT55, an orally active, highly-selective JAK2 inhibitor with an IC50 of 0.031 μM, inhibits proliferation of JAK2 V617F-expressing HEL cell lines, induces apoptosis and cycle arrest, and effectively inhibits HEL xenograft... |