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Search Results for " mtor-independent "

8

Compounds

Cat No. Product Name Synonyms Targets
T8055 TFEB activator 1 (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 Others , Autophagy
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.
T3155 SMER28 Autophagy
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide.
T12797 RU-SKI 43 RUSKI 43 Hedgehog/Smoothened , Acyltransferase
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compound for the treatment of lung adenocarcinomas.RU-SKI 43 reduc...
T16900 SMER18 Others
SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer.
T40483 8-Aminoadenosine 8-NH2-Ado
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy...
T79293 EGFR-IN-79 EGFR
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. It effectively induces cell death in proliferating and quiescent zones of E...
T76506 Coibamide A
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity alongside inducing autophagosome accumulation through an mTOR-independent mechanism and triggering apoptosis. Additio...
T10607 BRD5631 Autophagy
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, ...
TargetMol