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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8055 | TFEB activator 1 | (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612 | Others , Autophagy |
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease. | |||
T3155 | SMER28 | Autophagy | |
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide. | |||
T12797 | RU-SKI 43 | RUSKI 43 | Hedgehog/Smoothened , Acyltransferase |
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compound for the treatment of lung adenocarcinomas.RU-SKI 43 reduc... | |||
T16900 | SMER18 | Others | |
SMER18 is a small molecule enhancer of rapamycin which acts as an mTOR-independent autophagy inducer. | |||
T40483 | 8-Aminoadenosine | 8-NH2-Ado | |
8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy... | |||
T79293 | EGFR-IN-79 | EGFR | |
EGFR-IN-79 (compound 21), an EGFR inhibitor, exhibits antitumor activity through ROS-independent apoptosis and EGFR/AKT/mTOR-mediated autophagy. It effectively induces cell death in proliferating and quiescent zones of E... | |||
T76506 | Coibamide A | ||
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity alongside inducing autophagosome accumulation through an mTOR-independent mechanism and triggering apoptosis. Additio... | |||
T10607 | BRD5631 | Autophagy | |
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, ... |