Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease. [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,140.00 | |
50 mg | 10-14 weeks | $ 2,785.00 | |
100 mg | 10-14 weeks | $ 3,520.00 |
Description | BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease. [1]. |
In vitro | BRD5631 treatment (10 μM, 48 hours) elevates LC3-II levels in HeLa cells, indicating an enhancement in autophagosome formation. This activity aligns with the observed increase in autolysosome numbers in the mCherry-GFP-LC3 assay [1], suggesting BRD5631 promotes autophagy not by directly inhibiting mTOR or its signaling pathway but through alternative mechanisms. Additionally, BRD5631 reduces IL-1β secretion via an autophagy-dependent process, underscoring its potential as a modulator of autophagy-related functions [1]. |
Molecular Weight | 501.62 |
Formula | C30H35N3O4 |
CAS No. | 2446154-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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BRD5631 2446154-91-0 Autophagy BRD 5631 BRD-5631 inhibitor inhibit