mglur4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3565	VU0155041	UV0155041,VU-0155041	GluR
	VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).		GluR
T4500	ADX88178		GluR
	ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.		GluR
T13424	(1R,2S)-VU0155041		GluR
	(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.		GluR
T29135	VU0422288	VU-0422288,ML-396,ML396,VU 0422288,ML 396	GluR
	VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome...		GluR
T3464	PHCCC	(-) PHCCC	GluR
	PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.		GluR
T41301	L-Cysteinesulfinic acid monohydrate		GluR
	L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectiv...		GluR
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T6160	VU 0364439		GluR
	VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).		GluR
T29125	VU0359516	VU 0359516,VU-0359516
	VU0359516 is a mGluR4 positive allosteric modulators.
T11311L	Foliglurax	PXT002331	GluR
	Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).		GluR
T29121	VU0080241	VU-0080241,VU 0080241
	VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).
T11311	Foliglurax monohydrochloride	PXT002331 (monohydrochloride)	Others
	Foliglurax monohydrochloride Antiparkinsonian effect. is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM.		Others
T29133	VU0410150	VU-0410150,VU 0410150
	VU0410150, a pyrrylarylsulfone containing compound, has been found to be a mGluR4-positive allosteric modulator and has been evaluated as a potential drug for the treatment of Parkinson’s disease.
T11803	L-Cysteinesulfinic acid		Others
	L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs, pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and ...		Others
T3484	Trans-ACPD	Trans-(±)-ACP,1-amino-1,3-dicarboxycyclopentane,(±)-trans-ACPD	GluR
	trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/1...		GluR
T3486	3-MATIDA		GluR , NMDAR
	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3...		GluR , NMDAR
T23515	VU-29	VU 29	GluR
	VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).		GluR
T23507	VU0155041 sodium	VU 0155041 sodium salt	Others
	positive allosteric modulator/allosteric agonist of mGlu4 receptor		Others
T15456	GYKI 53655 hydrochloride	GYKI53655 hydrochloride,LY300168 hydrochloride	GluR
	GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.		GluR