20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9370 | DCBP-1 | Epigenetic Reader Domain , Ligand for E3 Ligase | |
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. | |||
T9116 | SMCC | N-Succinimidyl 4-(N-maleimidomethyl)cycl | Others |
SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker. | |||
T8667 | MC-Gly-Gly-Phe-Gly | DSN28369 | Others |
MC-Gly-Gly-Phe-Gly (DSN28369) is a heterobifunctional linker, and useful to make antibody drug conjuate (ADC). | |||
T14061 | EMCS | 6-Maleimidohexanoic acid N-hydroxysuccinimide ester | Others |
EMCS (6-Maleimidohexanoic acid N-hydroxysuccinimide ester) is a heterobifunctional crosslinking agent, which is a compound for the preparation of hapten conjugate and enzyme immune conjugate, and an effective protective ... | |||
T17389 | AMAS | Others | |
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules. | |||
T5440 | Dbet57 | Epigenetic Reader Domain | |
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2 | |||
T5434 | ARV-825 | Epigenetic Reader Domain | |
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. | |||
T21269 | Sulfo-EMCS | ||
Sulfo-EMCS is a heterobifunctional sulfhydryl- and amine-reactive crosslinker. | |||
T24842 | Sulfo-SIA Crosslinker | Sulfo-SIA Cross-linker,Sulfo-SIA Cross linker | |
Sulfo-SIA Crosslinker is a non-cleavable, heterobifunctional protein crosslinker. Sulfo-SIA Crosslinker is useful in making antibody-drug conjugates. | |||
T15395 | GMBS | Others | |
GMBS is a heterobifunctional cross-linker. | |||
T24841 | Sulfo-MBS Crosslinker | Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker | |
Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies. | |||
T18725 | Sulfo-LC-SPDP | Others | |
Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties. | |||
T18734 | Sulfo-SPP | Others | |
Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker. | |||
T19568 | Sulfo-SMPB sodium | Others | |
Sulfo-SMPB sodium is a non-cleavable heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups. This compound enables the covalent conjugation of molecules possessing... | |||
T15883 | M-PEG4-phosphonic acid ethyl ester | Others | |
m-PEG4-phosphonic acid ethyl ester is a PEGylation-based linker for the design and synthesis of PROTACs, which are heterobifunctional molecules facilitating targeted protein degradation[1]. | |||
T19943 | SMPB Crosslinker | SMPB Cross linker,SMPB Cross-linker | |
SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslin... | |||
T39352 | Piperidine-GNE-049-N-Boc | ||
Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, enabling it to be degraded by a selective and potent heterobifunctional degrader, p300/CBP. | |||
T40144 | CBP/p300 ligand 2 | ||
CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP. | |||
T18189 | M-PEG3-Sulfone-PEG4-propargyl | Others | |
m-PEG3-Sulfone-PEG4-propargyl is a polyethylene glycol (PEG)-based prodrug-induced degradation (PROTAC) linker. It is utilized in the efficient synthesis of PROTACs, a class of heterobifunctional molecules designed to se... | |||
T40036 | Thalidomide-NH-PEG4-COOH | Thalidomide-NH-PEG4-COOH | |
Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300/CBP. |