Home Tools
Log in
Cart

Search Result

Search Results for " geranylgeranyl "

17

Compounds

Cat No. Product Name Synonyms Targets
T40781L1 Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) Geranylgeranyl pyrophosphate tetrabutylammonium(1:2)(6699-20-3 Free base) Others
Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) is one of the endogenous cholesterol and intermediates produced by the mevalerate pathway. Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) is the common precursor...
T36863 Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate i...
T40781 Geranylgeranyl pyrophosphate
Geranylgeranyl pyrophosphate, a key metabolite in protein geranylgeranylation, serves as the universal precursor for diterpenoids, such as Paclitaxel. Its role in cancer research stems from this critical function.
T40781L Geranylgeranyl pyrophosphate tetrabutylammonium(1:1.5) Others
(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl dihydrogen diphosphate,tetrabutylammonium(1:1.5) is a common precursor of taxadiene such as Paclitaxel.
T25450 GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 NF-κB , Rho
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
T37693 N-acetyl-S-geranylgeranyl-L-Cysteine
N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f...
T83926 S-Geranylgeranyl-L-glutathione GGG
S-Geranylgeranyl-L-glutathione acts as a ligand for the orphan G protein-coupled receptor (GPCR) P2RY8, displaying selective affinity by inducing internalization of P2RY8 in preference to the sphingosine-1-phosphate rece...
T11282 FGTI-2734 Transferase
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat...
T12452 Digeranyl bisphosphonate DGBP Rho , Ras
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bisphosphonate induces autophagy but not apoptosis.
T3314 Perillyl alcohol Isocarveol,Perilla alcohol Apoptosis , Endogenous Metabolite
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-...
T35589 Geranyl pyrophosphate triammonium
Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the bios...
T11330L FTI-2148 Others
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively).
T11330 FTI-2148 diTFA Others
FTI-2148 diTFA, a dual inhibitor targeting both farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1), functions as a RAS C-terminal mimetic. It exhibits potent inhibitory capabilities with IC50 values of ...
T11282L FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate Others
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates ...
T69205 GGTI-2166
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo...
T72989 HGGPPS-IN-3 Apoptosis
Compound 13h (hGGPPS-IN-3) is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS), characterized as a C-2-substituted thienopyrimidine-based bisphosphonate analogue (C2-ThP-BPs). It selectively ind...
T63906 HGGPPS-IN-2
hGGPPS-IN-2 is an analogue of C-2 substituted thienopyrimidinyl bisphosphonates (C2-ThP-BPs) and is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 targets multiple myeloma (MM) ce...
TargetMol