dsdna — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11344	G150		DNA , cGAS
	G150 inhibited interferon expression triggered by DSDNA with IC50 of 10.2 nM.G150 is an effective and highly selective inhibitor of human cyclic GMP-AMP synthase (H-CGAS).		DNA , cGAS
T5486	RU.521	RU320521	DNA , cGAS
	RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.		DNA , cGAS
T38709	PFM39
	PFM39, a Mirin analog, is a potent and selective inhibitor of MRE11 exonuclease activity, specifically targeting the inhibition of phosphate rotation necessary for double-stranded DNA (dsDNA) exonuclease function. Import...
T83217	Abetimus	LJP 394 free base
	Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cell surfaces and reduce anti-dsDNA antibody levels, offering res...
T69663	G108
	G108 is a Novel h-cGAS specific inhibitor for repression of dsDNA-triggered interferon expression (IC50 of 27.5 nM and 5150 nM for h-cGAS and m-cGAS, respectively).
T82995	Antiviral agent 33
	Antiviral agent 33 (compound 1c), a double-stranded DNA (dsDNA) virus inhibitor, exhibits potent inhibitory activity with IC50 values of 0.0790 µM for VACV and 0.1572 µM for AdV5, and is a candidate for oral administrati...
T37904	Gadoleic Acid
	Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high...
T81640	NSC15520
	NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he...
TD0001	SYBR GREEN 1	SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO	Others
	SYBR Green I is an asymmetrical cyanine dye, which is used to detect nucleic acids. It consists of a N-alkylated benzothiazolium or benzoxazolium ring system, that is joined by a monomethine bridge to a pyridinium or qui...		Others
TD0003L	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO
	CelGreen nucleic acid gel stain 10,000× concentrate in DMSO is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak f...
T83668	Nucleic Acid Dye Green I	NucGel Green I Nucleic Acid Gel Stain,Green I Nucleic Acid Gel Stain
	Nucleic Acid Dye Green I, a cell-impermeable fluorescent dye, is widely utilized for quantifying both dsDNA and ssDNA due to its excitation and emission peaks at 497 nm and 520 nm, respectively. Additionally, it finds ap...
T36985	Cyclic di-UMP (sodium salt)
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or ds...
T75338	Acridine Orange base
	Acridine Orange Base, a cell-permeable fluorescent dye, selectively stains organisms (bacteria, parasites, viruses, etc.) bright orange and differentiates human cells in green under specific conditions (pH=3.5, Ex=460 nm...
TD0003	CelGreen nucleic acid gel stain 10,000× concentrate in water		Others
	CelGreen nucleic acid gel stain 10,000× concentrate in water is a fluorescent dye with a unique involvement that binds to all dsDNA double helix sulcus regions.In the free state, the side strand and CelGreen emit weak ...		Others
TD0002	CelRed nucleic acid gel stain 10,000× concentrate in water
	1) Non-toxicity: The unique oiliness and high molecular weight characteristics of CelRed prevent it from penetrating cell membranes into cells, and Ames test results also show that the mutagenicity of CelRed dye is much ...