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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T64159 | Cathepsin K inhibitor 2 | ||
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K (Cat K) is a cysteine protease expressed under the control of the CTSK gene, which is closely related to osteoporosis and hydrolyses collagen. cat... | |||
T72296 | Cathepsin K inhibitor 3 | ||
Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA). | |||
TP1015 | NFAT Inhibitor | VIVIT peptide | Others |
NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. | |||
T16394 | ONO-5334 | Cysteine Protease | |
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis. | |||
T6035 | Odanacatib | MK-0822 | Cysteine Protease |
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. | |||
T21616 | L-006235 | L 006235 | Cysteine Protease |
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM. | |||
T6015 | Cathepsin Inhibitor 1 | Cysteine Protease | |
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | |||
T16089 | MK-0674 | Cysteine Protease | |
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases. | |||
T7451 | 2-Cyanopyrimidine | 2-cyano-Pyrimidine | Cysteine Protease |
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM) | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
T6432 | Calpeptin | Apoptosis , Cysteine Protease , Proteasome | |
Calpeptin is a potent, cell-permeable calpain inhibitor. | |||
T16092 | L-873724 | Others | |
L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective... | |||
T71603 | MV061194 | ||
MV061194 is a potent and selective cathepsin K (Cat K) inhibitor. | |||
T40463 | Relacatib | SB-462795 | |
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac... | |||
T24564 | NVP-ABJ688 | ABJ-688,ABJ 688,ABJ688 | |
NVP-ABJ688 is the cysteine protease cathepsin K inhibitor. | |||
T60838 | Gü2602 | ||
Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature CatK (mCatK) [1]. | |||
T74154 | ABP 25 | ||
ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging. | |||
T61413 | Gü1303 | ||
Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK). This compound effectively suppresses the autocatalytic activation of the CatK zymogen [1]. | |||
T80092 | Z-Gly-Pro-Arg-AMC hydrochloride | ||
Z-Gly-Pro-Arg-AMC hydrochloride is a fluorescent substrate for both trypsin and cathepsin K, utilized to assay their respective enzymatic activities [1] [2]. | |||
T80108 | Hepcidin-1 (mouse) | ||
Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intra... |