xii — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T80498	Jingzhaotoxin-XII	JzTx-XII	Potassium Channel
	Jingzhaotoxin-XII (JzTx-XII) functions as a potent inhibitor of the Kv4.1 channel, exhibiting an inhibitory concentration (IC50) of 0.363 μM. It modulates the channel's gating behavior [1].		Potassium Channel
T21949	Calpain Inhibitor XII
	(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)...
T125110	Eupteleasaponin XII
	Eupteleasaponin XII is a useful organic compound for research related to life sciences. The catalog number is T125110 and the CAS number is 290809-58-4.
T125868	RA-XII
	RA-XII is a useful organic compound for research related to life sciences. The catalog number is T125868 and the CAS number is 143343-98-0.
T78789	HCA XII-IN-6		Carbonic Anhydrase
	Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative effects, making it useful in cancer research [1].		Carbonic Anhydrase
T79351	JH-XII-03-02		PROTACs
	JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PD) research [1].		PROTACs
T17281	Z-Ile-Leu-aldehyde	Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII	Others
	Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.		Others
T79753	HCAIX/XII-IN-8		Carbonic Anhydrase
	hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7 nM for CA XII. It demonstrates significant inhibitory effi...		Carbonic Anhydrase
T61384	HCAIX/XII-IN-4
	hCAIX/XII-IN-4 (compound 6c) is a highly potent inhibitor of CAIX/XII. It exhibits Ki values of 4.5 nM, 23.6 nM, >10000 nM, and >10000 nM for CAXII, CAIX, CAI, and CAⅡ, respectively [1].
T61959	HCAIX/XII-IN-3
	hCAIX/XII-IN-3 (compound 6q) is a potent, selective inhibitor of hCAIX and hCAXII. hCAIX/XII-IN-3 shows K i values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
T61015	HCAIX/XII-IN-2
	hCAIX/XII-IN-2 (compound 6a) is a potent and selective inhibitor of hCAIX and hCAXII. The Ki values of hCAIX/XII-IN-2 for hCAI, hCAII, hCAIX and hCAXII are >10000, >10000, 30.0, 3.6 nM, respectively [1].
T72840	HCAIX/XII-IN-6
	hCAIX/XII-IN-6, an orally active carbonic anhydrase (CA) inhibitor, targets human CA isoforms hCA I, II, IV, IX, and XII with inhibition constants (K i) of 6697 nM, 2950 nM, 4093 nM, 4.1 nM, and 7.7 nM, respectively. Thi...
T79748	HCAIX/XII-IN-7		Carbonic Anhydrase
	Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for hCA IX and 59 nM for hCA XII, while also showing activity ag...		Carbonic Anhydrase
T60602	HCAIX/XII-IN-5
	hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative ...
T61873	HCAIX/XII-IN-1
	hCAIX/XII-IN-1, a potent inhibitor of both CAIX and CAXII, exhibits KI values of 0.48 μM for CAIX and 0.83 μM for CAXII, respectively. This compound demonstrates antiproliferative activity in vitro and induces apoptosis ...
T63400	HA2A/hCA XII modulator 1
	hA2A/hCA XII modulator 1 is a potent antagonist of the hA2A adenosine receptor (hA2AAR), a triazolopyrazine that acts on hA2AAR (Ki: 6.4 nM), hA1AR (Ki: 4.819 μM), and hA3AR (Ki>30 μM). hA2A/hCA XII modulator 1 Also a po...
T25779	MDK-4683	MDK 4683,CA IX/XII Inhibitor
	MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.
T63764	HCA XII/II/IX-IN-1
	hCA XII/II/IX-IN-1 is a potent inhibitor of human carbonic anhydrase (hCA) and is able to act on hCA I (IC50: 2.6 μM), hCA II (IC50: 0.004 μM), hCA IX (IC50: 0.005 μM) and hCA XII (IC50: 0.001 μM). hCA XII/II/IX -IN-1 ex...
T4502	BISMUTH SUBGALLATE	Dermatol Puder,Bismuth Gallate	Others
	Bismuth subgallate (Dermatol Puder) is an astringent and antiseptic and is applied to skin diseases such as eczema.		Others
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase