vcap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21740	RD162		Androgen Receptor
	RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).		Androgen Receptor
T10359	AR antagonist 1		Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC
	AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
TP1093	TAK-448 acetate	TAK-448 acetate (1234319-68-6 Free base),MVT-602 acetate	Kisspeptin
	TAK-448 acetate (MVT-602 acetate) is a small molecule KISS1R agonist, a synthetic peptide similar to kisspeptin.TAK-448 acetate has antitumor activity, inhibits the proliferation of VCaP cells, and can be used in prostat...		Kisspeptin
T39695	ARD-2128		Androgen Receptor
	ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...		Androgen Receptor
T78811	PROTAC AR-NTD degrader 1		Androgen Receptor
	PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antago...		Androgen Receptor
T74745	A031
	A031, a potent PROTAC androgen receptor (AR) degrader, demonstrates significant efficacy with an IC50 value under 0.25 μM for AR protein degradation. Additionally, it exhibits an inhibitory impact on tumor growth in zebr...
T79725	ARD-1676		Androgen Receptor
	ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activity both in vitro and in vivo, and effectively inhibits VCaP ...		Androgen Receptor
T78922	ARD-2051		PROTACs
	ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading AR protein within LNCaP and VCaP prostate cancer cell lines. It hold...		PROTACs
T13552	ARD-266		Others
	ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s...		Others
T17689	Boc-Pip-alkyne-Ph-COOH		Others
	Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degra...		Others
T13958	VHL Ligand 8		Others
	VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p...		Others
T78810	BWA-522		Androgen Receptor
	BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) and the AR-V7 splice variant. It specifically antagonizes the...		Androgen Receptor
T30123	ARD-69
	ARD-69 is a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. ARD-69 induces degradation of AR protein in AR-positive prostate cancer cell lines...