trka-in-3 — TargetMol Chemicals

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Search Results for " trka-in-3 "

Compounds

Cat No.	Product Name	Synonyms	Targets
T73306	TrkA-IN-3
	TrkA-IN-3 is a potent, subselective, and allosteric inhibitor of TrkA, demonstrating significant potency with an IC50 of 22.4 nM. It exhibits over 8000-fold selectivity towards TrkA in comparison to TrkB and TrkC, making...
T3678	Entrectinib	RXDX-101,NMS-E628	Trk receptor , ROS , ALK , Autophagy , ROS Kinase
	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...		Trk receptor , ROS , ALK , Autophagy , ROS Kinase
T73307	TrkA-IN-4
	TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a prodrug of TrkA-IN-3 . TrkA-IN-4 exhibits potent antinociceptive effects [1] .
T61712	Trk-IN-8
	Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1].
T61551	Trk-IN-20
	Trk-IN-20 is a 3-vinylindazole derivative compound that effectively inhibits the functions of Trk kinases. It accomplishes this by suppressing the phosphorylation of TrkA, TrkB, and TrkC, with IC50 values of 1.6 nM, 2.9 ...
T64070	Pan-Trk-IN-3
	Pan-Trk-IN-3 is a potent, broad-spectrum inhibitor of Trk and its drug-resistant mutants, acting on TrkA (IC50: 2 nM), TrkB (IC50: 3 nM), TrkC (IC50: 2 nM), TrkAG595R (IC50: 21 nM), TrkAG667C (IC50: 26 nM), TrkAG667S (IC...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched i...