9
3
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13216 | TSHR antagonist S37 | TSH Receptor | |
TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR). | |||
T38226 | TSHR antagonist S37b | ||
TSHR antagonist S37b, the less potent enantiomer of TSHR antagonist S37a, exhibits minimal efficacy in inhibiting the thyrotropin receptor (TSHR). It is utilized in thyroid function research[1]. | |||
T13217 | TSHR antagonist S37a | Others | |
TSHR antagonist S37a is a selective antagonist of thyrotropin receptor (TSHR), with potential for the treatment of Graves' orbitopathy. | |||
T29087 | VA-K-14 hydrochloride | VAK14 Hydrochloride,VA K 14 HCl,VA-K-14 HCl,VAK14 HCl | TSH Receptor |
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogate... | |||
T5383 | D3-βArr | NCGC00379308 | TSH Receptor |
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation. | |||
T16106 | ML224 | NCGC00242364,ANTAG3 | TSH Receptor |
ML224 (NCGC00242364) is a TSHR antagonist for the treatment of Graves' orbital disease and Graves' hyperthyroidism. | |||
T12073 | ML-109 | TSH Receptor | |
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM) | |||
T12192 | NCGC00229600 | Others , TSH Receptor | |
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies. | |||
T16403 | Org41841 | Org-41841 | TSH Receptor |
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04853 | TSHR Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed pre... | |||
TMPH-02685 | GPHB5 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce... | |||
TMPH-02684 | GPHB5 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid ce... |